The question proposed by the current study is: Is there a combination of biomechanics, biochemistry, and MRI-detectible ACL biological composition which can cumulatively and accurately predict ACL injury risk? The long-term goals are three-fold. (1) determine a complete ACL injury risk profile by evaluating biomechanics, biochemistry, and ACL biological composition, (2) develop a useful screening protocol for at-risk athletes for the purpose of implementing a prevention/training regimen to reduce the overall risk of ACL injury, and (3) better characterize the success of ACL reconstructive surgery for restored biomechanics and joint health (i.e. osteoarthritis initiation) following injury. The figures below are from Andriacchi et al., 2009.